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KMID : 0604520180440040465
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 4 p.465 ~ p.475
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Studies on Antioxidant, Anti-inflammation and Tyrosinase Inhibitory Activities of Melissa officinalis Extracts and Their Fractions
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Jeong Yong-Un
Lee Hwan
Park Ha-Ney
Kim Kyung-Min
Kim Su-Yeong
Park Young-Jin
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Abstract
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This study was carried out to evaluate the antioxidant, anti-inflammation, and tyrosinase inhibitory activity of Melissa officinalis extracts and their fractions. The total polyphenol contents of the extracts were 33.02-302.76 mg GAE/g and total flavonoid contents were 9.98-325.07 mg CE/g. In 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, DPPH radical scavenging activity was observed in the extracts and water fractions of M. officinalis and similar to that of ascorbic acid (30 μM). In addition, the treatment of chloroform fraction significantly inhibited the production of nitric oxide (NO) in RAW 264.7 cells, indicating that they have anti-inflammatory activity. Tyrosinase inhibitory activity of 200 μg/mL of 100% ethanol reflux extract showed better inhibitory activity than arbutin treatment at statistically significant level. As a result, it is considered that M. officinalis can be used as an effective cosmetic ingredient having antioxidant, anti-inflammation, and whitening activity.
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KEYWORD
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antioxidant, anti-inflammation, tyrosinase, M. officinalis, whitening activity
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